Study on the relationship between Diabetes family history and risk of abnormal blood sugar

• Main Authors: Fang-i Hsu, 徐芳儀
• Other Authors: Hong-zhe Jiang
• Format: Others
• Language: zh-TW
• Published: 2007
• Online Access: http://ndltd.ncl.edu.tw/handle/57394829821178194792

碩士 === 高雄醫學大學 === 醫學研究所碩士班 === 95 === Background ― Diabetes is one of the most important public health topics in the 21st century. Early diagnosis and prevention are helpful to control and improve the disease.We aimed to evaluate the risks of diabetes among subjects with or without diabetes family history and subjects who live with or without diabetes patients. We hope to develop relationships between diabetes and it’s risk fators such as genetic or environment . Methods ―We collected 223 volunteers subjects with diabetes family history from family members of diabetes patients presented at policlinic or a medical center and a district hospital. We also selected 1199 subjects who answered no diabetes family history known from a data bank of health survey in a community near by the two hospitals.Subjects with diabetes family history was matched by the ratio of 1:3 with sex, age: +-2 years old.The OR of diabetes for risk factors of lineal relations ( father,mother,father and mother),were seel in subjects of case and control groups. Results ― After compared and analyzed the different groups, the study found out that the person who has diabetes family history has better chance than the non- diabetes family history person to suffer from the trouble blood sugar. The risk of having blood sugar anomaly for the person who has the diabetes family history is 3.5 times higher than the person who has non- diabetes family history(95% CI=2.02-6.07, p=0.000). Also the person who lives with the diabetes family history people has better chance to suffer from the blood sugar diseases than the person who doesn’t live with the diabetes family history people. Compare between people who live with and without diabetes patients, people who live with diabetes patients has high chance of getting diabetes. If two people both live without diabetes patient, one come from diabetes history family and the other from non-diabetes family. The ratio of getting diabetes is 25.3% to 13.7%. The risk of blood sugar anomaly is 3.17 times (95% CI=1.70-5.91, p=0.000) higher than the person who has non- diabetes family history and not living with diabetes patient. On the other hand, a person who comes from a diabetes history family and lives with a diabetes patient has 38.5% more chance of having blood sugar anomaly than a person who come form a diabetes history family and does not live with a diabetes patient. In addition, the risk of blood sugar anomaly is 5.59 times higher than a person who has non- diabetes family history and does not lives with diabetes patient. (95% CI=2.57-12.16, p=0.000). In the group age 45 and above, the risk of blood sugar anomaly is 4.21 times higher for a person who has diabetes family history but doesn’t live with diabetes patients than a person from a non-diabetes history family and no diabetes patient in the house hood. (95% CI=2.16-8.22, p=0.001). In addition it is 8.28 times higher than a person who has diabetes family history and lives with a diabetes patient (95% CI=3.40-20.15, p=0.000). On the other hand, lineal relatives affect the chance of getting diabetes the most then collateral relatives and in-law relatives. The risk of blood sugar anomaly in lineal group is 4.21 times higher than a person who has not have diabetes family history (95% CI=2.57-8.14, p=0.000). Conclusions ―In the current study,we found family history of diabetes and the similarity of living condition or habits were important risk factors of blood sugar anomaly. By having a closer blood relationship to the diabetes patient will higher the chance to get diabetes and blood sugar exceptionally, especially in the older people. For early prevention of diabetes and control of blood sugar population with these two characteristics should be targeted as priority of prevention measures.