Association between schizophrenia and haplotype of interleukin-10 gene promoter region

• Main Authors: Hsin-Yi Peng, 彭馨儀
• Other Authors: Yong-yuan Chang
• Format: Others
• Language: zh-TW
• Published: 2007
• Online Access: http://ndltd.ncl.edu.tw/handle/40046048693458924940

碩士 === 高雄醫學大學 === 公共衛生學研究所碩士班 === 95 === Objective：The aim of this study was to find association of gene frequency, allele frequency and haplotype of three single nucleotide polymorphism (-1082*G/A、-819*T/C、-592*C/A) on interleukin-10 gene promoter region between schizophrenia and general population. Methods：This study was case-control designed. The subjects were random sampling from a community in southern Taiwan. The cases were diagnosed schizophrenia by DSM-IV at a teaching hospital in southern Taiwan. Results：Both allele frequency and genotype frequency were significant on -1082*G/A of interleukin-10 gene promoter region between schizophrenia and general population(X2 =4.959、p=0.026；X2 =7.691、p=0.021). However, on -819*T/C of interleukin-10 gene promoter region, there was allele frequency significant(X2 =0.830、p=0.046). Furthermore, we used genetic software—UNPHASED and PHASE—to analyze haplotype frequency. The result showed that haplotype ACA was related to schizophrenia(p=0.000；p=0.002). Conclusion：Haplotype ACA on interleukin-10 gene promoter region was related to schizophrenia. The polymorphism could affect imbalanced secretion of Th1/Th2. This suggested that the effect might have relations with the etiology of schizophrenia.