| Summary: | 碩士 === 義守大學 === 生物醫學工程學系碩士班 === 95 === Arterial hardening is not only intensely harmful to human, but frequently associated with cardiovascular disease. Many studies consider the vascular compliance (C0) to be a constant, which is not consistent with the newest results. Thus, the goal of this thesis was to measure and model the time-varying arterial compliance. In 16 volunteers, their continuous blood pressure waveform and vessel volume waveform were recorded respectively by a blood pressure waveform device using oscillometry and a vessel volume device using photoplethysmography designed in the thesis. Beat-to-beat analysis of vascular compliance was carried out in the maximum breath-hold maneuver divided into four phases, including the baseline, initial breath-hold, middle breath-hold and maximum breath-hold. Meanwhile, intrabeat analysis between the arterial pressure and volume variations was also determined in the baseline and last breath-hold phases. In addition, computer modeling was performed based on the minute vibration theory. The beat-to-beat results showed that C0 was significantly decreased in the initial and last breath-hold phases (for both, p < 0.03), as compared to the baseline C0. Also, arterial distensibility (CV) was significantly elevated in the initial breath-hold phase than in the control, with no significant change in the vascular plasticity (CP). The intrabeat analysis showed that C0, CP and CV in the ascending portion of the arterial pressure were increased in the maximum breath-hold phase that the control in 13 of the 16 volunteers. Additionally, the modeling result was consistent with the previous one. In this thesis, the oscillometry-based pressure device and the photoplethysmography-based vessel volume device have been constructed and are available for the breath-hold experiments. Also finished is the beat-to-beat and intrabeat analysis of the three kinds of vascular compliance.
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