| Summary: | 碩士 === 中山醫學大學 === 營養學研究所 === 95 === Pearl is one traditional Chinese medicine, which contains a lot of amino acids and minerals. Many animal studies indicate that pearl has antioxidation and anti-aging effect.
The study was focused on antioxidant effect and anti-aging ability of pearl powder. Results showed that both pearl powder and protein extract of pearl powder had antioxidation and scavenging efficiency on free radicals.
For anti-aging function, wild-type Caenorhabditis elegans was used. Protein extract of pearl powder effectively extended the life span. Protein was probably the main contribution of antioxidation for pearl. To further evaluate the effect of pearl powder on antioxidation in human body. The study employed a randomized, placebo-controlled design. Nineteen subjects were enrolled respectively in a ten-week trial. Each subject ate 3g of pearl powder capsule or placebo every day for continuous eight weeks. The total experimental period was ten weeks, including eight weeks of administration and two weeks of follow-up. Anthropometric measurements, blood collecting were performed at the initial, 2nd, 4th, 6th, 8th, 10th weeks of the testing period. Pearl powder greatly increased total antioxidant capacity, total thiol group levels, contents of glutathione, and reduced thiobarbituric acid reactive substance (TBARS) in plasma. The antioxidant enzyme activity in erythrocytes was also increased, including glutathione peroxidase and glutathione reductase. In additional, oxidative lag time of LDL was significantly increased from 43.50 to 58.00 mins.
In conclusion, pearl powder showed great antioxidation. The main contribution was probably from its protein.
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