The antioxidant activity of s-ethyl cysteine and s-methyl cysteine at various doses-Diabetic animal model

• Main Authors: Pei-Fang, 蔣佩芳
• Other Authors: 殷梅津
• Format: Others
• Language: zh-TW
• Published: 2007
• Online Access: http://ndltd.ncl.edu.tw/handle/89616431096655837463

碩士 === 中山醫學大學 === 營養學研究所 === 95 === Diabetes is one of the major chronic diseases in Taiwan. It is hardly controlled because of its complications. This study was to examine the protection from S-methyl cysteine (SMC) and S-ethyl cysteine (SEC), two sulfur compounds derived from garlic, against diabetic deterioration in streptozotocin-induced diabetic mice. These agents were added at 2 g/L (high dose, H), 1 g/L (medium dose, M), and 0.5 g/L(low dose, L) in drinking water for 4 weeks supplementation. Blood levels of glucose, insulin, glutathione peroxidase, fibronectin, caretinine, blood urea nitrogen, c-reactive protein, transforming growth factor-beta and lipid oxidation were analyzed. Results showed that the intake of both agents could significantly decrease blood glucose and BUN (p<0.05), and increase GPX activity (p<0.05). The intake of SMC could significantly suppress fibronectin level and TGF-β (p<0.05). These results indicated that the intake of SEC and/or SMC could alleviate diabetic deterioration.