The physical and stable property investigation of Epidermal Growth Factor encapsulated liposome

碩士 === 嘉南藥理科技大學 === 化妝品科技研究所 === 95 === Epidermal Growth factor (EGF) was encapsulated into liposome in order to protect it from the degradation. In this study, we examined the stability of EGF in different formulation including O/W lotion, W/O lotion and liposomes. Three phospholipids including LS-...

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Main Authors: Ying-YU Chen, 陳盈如
Other Authors: Wei-chao Lin
Format: Others
Language:zh-TW
Published: 2007
Online Access:http://ndltd.ncl.edu.tw/handle/70632705774209100363
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spelling ndltd-TW-095CNUP57930172015-10-13T15:42:15Z http://ndltd.ncl.edu.tw/handle/70632705774209100363 The physical and stable property investigation of Epidermal Growth Factor encapsulated liposome 包覆生長因子之微脂粒物性與安定性探討 Ying-YU Chen 陳盈如 碩士 嘉南藥理科技大學 化妝品科技研究所 95 Epidermal Growth factor (EGF) was encapsulated into liposome in order to protect it from the degradation. In this study, we examined the stability of EGF in different formulation including O/W lotion, W/O lotion and liposomes. Three phospholipids including LS-60HR, NC-20, NC-21 were employed for the preparation of liposome, in which only NC-20 is a non-hydrogenated lecithin. The results showed that the diameters of liposomes were around 110~150 nm. The diameter of NC-20 was smaller than that of hydrogenated lecithin LS-60HR and NC-21. The encapsulation efficiency of the EGF liposome with and/or without extrusion through polycarbonate filter were more than 80% and about 60% respectively. For the stability evaluation, the EGF activity in both O/W lotion and W/O lotion decreased to only 10% at 45℃ after ten-days, but these samples if encapsulated into liposomes could keep above 50% of activity at 45℃ after thirty-days. These results indicate that these liposomes effectively retains the activity of EGF. Wei-chao Lin 林維炤 2007 學位論文 ; thesis 61 zh-TW
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description 碩士 === 嘉南藥理科技大學 === 化妝品科技研究所 === 95 === Epidermal Growth factor (EGF) was encapsulated into liposome in order to protect it from the degradation. In this study, we examined the stability of EGF in different formulation including O/W lotion, W/O lotion and liposomes. Three phospholipids including LS-60HR, NC-20, NC-21 were employed for the preparation of liposome, in which only NC-20 is a non-hydrogenated lecithin. The results showed that the diameters of liposomes were around 110~150 nm. The diameter of NC-20 was smaller than that of hydrogenated lecithin LS-60HR and NC-21. The encapsulation efficiency of the EGF liposome with and/or without extrusion through polycarbonate filter were more than 80% and about 60% respectively. For the stability evaluation, the EGF activity in both O/W lotion and W/O lotion decreased to only 10% at 45℃ after ten-days, but these samples if encapsulated into liposomes could keep above 50% of activity at 45℃ after thirty-days. These results indicate that these liposomes effectively retains the activity of EGF.
author2 Wei-chao Lin
author_facet Wei-chao Lin
Ying-YU Chen
陳盈如
author Ying-YU Chen
陳盈如
spellingShingle Ying-YU Chen
陳盈如
The physical and stable property investigation of Epidermal Growth Factor encapsulated liposome
author_sort Ying-YU Chen
title The physical and stable property investigation of Epidermal Growth Factor encapsulated liposome
title_short The physical and stable property investigation of Epidermal Growth Factor encapsulated liposome
title_full The physical and stable property investigation of Epidermal Growth Factor encapsulated liposome
title_fullStr The physical and stable property investigation of Epidermal Growth Factor encapsulated liposome
title_full_unstemmed The physical and stable property investigation of Epidermal Growth Factor encapsulated liposome
title_sort physical and stable property investigation of epidermal growth factor encapsulated liposome
publishDate 2007
url http://ndltd.ncl.edu.tw/handle/70632705774209100363
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