Routes in the human brain microvessel endothelial cells and permeability of the in vitro Blood-Brain Barrier of saquinavir entrapped by cationic solid lipid nanoparticles

碩士 === 國立中正大學 === 化學工程所 === 95 === Saquinavir (SQV), an anti-human immunodeficiency virus agent, was incorporated in cationic solid lipid nanoparticles (cationic SLN) to promote the permeability of in vitro blood-brain barrier (BBB). Moreover, the uptake of cationic SLN by endothelial vesicles, form...

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Bibliographic Details
Main Authors:	Hung-hao Chen, 陳弘浩
Other Authors:	Yung-Chih Kuo
Format:	Others
Language:	zh-TW
Published:	2007
Online Access:	http://ndltd.ncl.edu.tw/handle/38716175245113011083

id	ndltd-TW-095CCU05063045
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spelling	ndltd-TW-095CCU050630452015-10-13T11:31:38Z http://ndltd.ncl.edu.tw/handle/38716175245113011083 Routes in the human brain microvessel endothelial cells and permeability of the in vitro Blood-Brain Barrier of saquinavir entrapped by cationic solid lipid nanoparticles 包覆Saquinavir的cationicSLN在人腦微血管內皮細胞裡的運輸路徑和生體外血腦阻障模型的穿透 Hung-hao Chen 陳弘浩碩士國立中正大學化學工程所 95 Saquinavir (SQV), an anti-human immunodeficiency virus agent, was incorporated in cationic solid lipid nanoparticles (cationic SLN) to promote the permeability of in vitro blood-brain barrier (BBB). Moreover, the uptake of cationic SLN by endothelial vesicles, formed by human brain microvessel endothelial cells, was confirmed. Cationic SLN with optimum drugs entrapment effect was composed of Compritol 888 ATO, cacao butter, as lipid matrix, and dimethyldioctadecylammonium bromide, octadecylamin, as cationic lipid. Nuclear magnetic resonance and drugs release experiment were performed to investigate the distribution of SQV in lipid matrix. As the contant of SA increased, cytotoxicity of cationic SLN after drugs release experiment increased. Cationic SLN was efficacious carrier of SQV to meliorate BBB permeability by 17 folds, 22 folds was enhanced under electromagnetic field with amplitude modulation. Yung-Chih Kuo 郭勇志 2007 學位論文 ; thesis 100 zh-TW
collection	NDLTD
language	zh-TW
format	Others
sources	NDLTD
description	碩士 === 國立中正大學 === 化學工程所 === 95 === Saquinavir (SQV), an anti-human immunodeficiency virus agent, was incorporated in cationic solid lipid nanoparticles (cationic SLN) to promote the permeability of in vitro blood-brain barrier (BBB). Moreover, the uptake of cationic SLN by endothelial vesicles, formed by human brain microvessel endothelial cells, was confirmed. Cationic SLN with optimum drugs entrapment effect was composed of Compritol 888 ATO, cacao butter, as lipid matrix, and dimethyldioctadecylammonium bromide, octadecylamin, as cationic lipid. Nuclear magnetic resonance and drugs release experiment were performed to investigate the distribution of SQV in lipid matrix. As the contant of SA increased, cytotoxicity of cationic SLN after drugs release experiment increased. Cationic SLN was efficacious carrier of SQV to meliorate BBB permeability by 17 folds, 22 folds was enhanced under electromagnetic field with amplitude modulation.
author2	Yung-Chih Kuo
author_facet	Yung-Chih Kuo Hung-hao Chen 陳弘浩
author	Hung-hao Chen 陳弘浩
spellingShingle	Hung-hao Chen 陳弘浩 Routes in the human brain microvessel endothelial cells and permeability of the in vitro Blood-Brain Barrier of saquinavir entrapped by cationic solid lipid nanoparticles
author_sort	Hung-hao Chen
title	Routes in the human brain microvessel endothelial cells and permeability of the in vitro Blood-Brain Barrier of saquinavir entrapped by cationic solid lipid nanoparticles
title_short	Routes in the human brain microvessel endothelial cells and permeability of the in vitro Blood-Brain Barrier of saquinavir entrapped by cationic solid lipid nanoparticles
title_full	Routes in the human brain microvessel endothelial cells and permeability of the in vitro Blood-Brain Barrier of saquinavir entrapped by cationic solid lipid nanoparticles
title_fullStr	Routes in the human brain microvessel endothelial cells and permeability of the in vitro Blood-Brain Barrier of saquinavir entrapped by cationic solid lipid nanoparticles
title_full_unstemmed	Routes in the human brain microvessel endothelial cells and permeability of the in vitro Blood-Brain Barrier of saquinavir entrapped by cationic solid lipid nanoparticles
title_sort	routes in the human brain microvessel endothelial cells and permeability of the in vitro blood-brain barrier of saquinavir entrapped by cationic solid lipid nanoparticles
publishDate	2007
url	http://ndltd.ncl.edu.tw/handle/38716175245113011083
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Routes in the human brain microvessel endothelial cells and permeability of the in vitro Blood-Brain Barrier of saquinavir entrapped by cationic solid lipid nanoparticles

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