In Vivo Study of Injectable PLA/Chitosan/ACP GTR Barrier

• Main Authors: Chan Chinchung, 詹進忠
• Other Authors: Lin Chetong
• Format: Others
• Language: zh-TW
• Published: 2006
• Online Access: http://ndltd.ncl.edu.tw/handle/35708801463241362390

碩士 === 臺北醫學大學 === 牙醫學系 === 94 === The goal of the study is to evaluate the effects and limitation of injectable PLA/chitosan/ACP GTR barrier in animal study. This study is further divided into two parts: In the first part of the study, 5-mm supra-alveolar periodontal defects were surgically created in 4 beagle dogs. Defects were treated with PLA/chitosan/ACP, PLA/doxycycline, PLA or Atrisorb®, the last group was treated with flap suture only as control. Alveolar bone and cementum regeneration were evaluated after 8 weeks. In the second part, 4x5 mm 2-wall intrabony defects were surgically created in 2 beagle dogs. The defects were treated with PLA/chitosan, PLA/doxycycline, Atrisorb®, while DFDBA was filling into defects as scaffold, be treated with flap suture only and DFDBA only as control. The effect of periodontal regeneration to GTR combined with DFDBA scaffold was evaluated after 4 and 12 weeks. Increasing height of alveolar bone regeneration was found in all groups in the second study. The above results confirmed the efficacy of PLA/chitosan barrier in preventing the apical migration of epithelial cell and inducing new bone formation. Therefore, its application in guided tissue regeneration with DFDBA is feasible.