Studies on The Model Catechol 1,2-Dioxygenase Iron(III) Complexes

• Main Authors: Chi-Huang Weng, 翁啟煌
• Other Authors: Ho-Hsiang Wei
• Format: Others
• Language: zh-TW
• Published: 2004
• Online Access: http://ndltd.ncl.edu.tw/handle/74389229861138634191

碩士 === 淡江大學 === 化學學系碩士班 === 94 === A seiries of iron(III) complexes as funtionl model compounds for catechol 1,2-dioxygenases (intradiol cleavage) were synthesized and characterized by X-ray single crystal diffraction, UV-Vis spectroscopy, element analyzer, and electronchemical analysises.Enzyme-substrate complexes and ligands: (1) [Fe(L1)(C6Br4O2)] (2) [Fe(L1)(C6Cl4O2)] (3) [Fe(L2)(C6Cl4O2)] (4) [Fe(L3)(C6Cl4O2)] (5) [Fe(L4)(C6Cl4O2)] L1: 2-{[2-(2-diethylamino-ethylamino)-ethylimino]-methyl}-phenol L2: 2-{[2-(2-diethylamino-ethylamino)-ethylimino]-methyl}-5-bromo-phenol L3: 2-{[2-(2-diethylamino-ethylamino)-ethylimino]-methyl}-4,6-methoxy-phenol L4: 2-{[2-(2-diethylamino-ethylamino)-ethylimino]-methyl}-3-methoxy-phenol Catechol 1,2-dioxygenase reactivity has been performed by electronic spectrum in methanol/acetonitrile solutions. The solutions are contained [Fe(L1~4)Cl2] with catecholate anions of tetrabromocatechol(TBC), tetrachlorocatechol(TCC),catechol(HC), and 3,5-di-tert-butylcatechol(3,5-DTBC). The results show that the high lewis acidity iron(III) complexes [Fe(L2) 3,5-DTBC] exhibits the higher catechol 1,2-dioxygenase reactivity.