| Summary: | 碩士 === 淡江大學 === 化學學系碩士班 === 94 === A seiries of iron(III) complexes as funtionl model compounds for catechol 1,2-dioxygenases (intradiol cleavage) were synthesized and characterized by X-ray
single crystal diffraction, UV-Vis spectroscopy, element analyzer, and electronchemical analysises.Enzyme-substrate complexes and ligands:
(1) [Fe(L1)(C6Br4O2)]
(2) [Fe(L1)(C6Cl4O2)]
(3) [Fe(L2)(C6Cl4O2)]
(4) [Fe(L3)(C6Cl4O2)]
(5) [Fe(L4)(C6Cl4O2)]
L1: 2-{[2-(2-diethylamino-ethylamino)-ethylimino]-methyl}-phenol
L2: 2-{[2-(2-diethylamino-ethylamino)-ethylimino]-methyl}-5-bromo-phenol
L3: 2-{[2-(2-diethylamino-ethylamino)-ethylimino]-methyl}-4,6-methoxy-phenol
L4: 2-{[2-(2-diethylamino-ethylamino)-ethylimino]-methyl}-3-methoxy-phenol
Catechol 1,2-dioxygenase reactivity has been performed by electronic spectrum in methanol/acetonitrile solutions. The solutions are contained [Fe(L1~4)Cl2] with catecholate anions of tetrabromocatechol(TBC), tetrachlorocatechol(TCC),catechol(HC), and 3,5-di-tert-butylcatechol(3,5-DTBC). The results show that the high lewis acidity iron(III) complexes [Fe(L2) 3,5-DTBC] exhibits the higher catechol 1,2-dioxygenase reactivity.
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