The metabolomic and functional genomic studies of protein stability

• Main Authors: chiou da peng, 邱大朋
• Other Authors: jang ching yau
• Format: Others
• Language: zh-TW
• Published: 2007
• Online Access: http://ndltd.ncl.edu.tw/handle/39348742052139567922

碩士 === 亞洲大學 === 生物資訊學系碩士班 === 94 === In the field of proteomics and genomics, it is primary subjects to solve out the sequences and structures, but not all proteins can solve out their structures smoothly, so we analyse through the integration of the database that can find out more meaningful information, and then we combine the algorithm of predict the protein temperature stability that developed in the past in the laboratory : Temperature Index, and get Instability Index that predict the protein stability in protein’s half-life. Using their primary sequences to analyse these proteins which are been solving structures and separate the proteins that can not solve out the structures from that solve out into two kinds of structures to do analysis, and then go to predict the chance of solving out the structures of proteins that will begin to solve of the structures soon, and we make two algorithms to be on-line tool , stabilize under tool of factor cooperate through two focus each other in different protein, leave an more accurate suggestion on users, web lie between Taxi on-line tool development its stabilize under tool of factor cooperate through two focus each other in different protein, leave a more accurate suggestion on users, can use the analysis of making an amendment in protein project .