The Development of Transdermal Drug Delivery System for Beta-Thalassaemia Major

• Main Authors: Chin-Hsiung Hsieh, 謝錦雄
• Other Authors: 黃義侑
• Format: Others
• Language: zh-TW
• Published: 2006
• Online Access: http://ndltd.ncl.edu.tw/handle/33450550369343563604

碩士 === 國立臺灣大學 === 醫學工程學研究所 === 94 === The ultimate goal of this study is to help thalassemia major patients, who chronically require blood transfusions to keep alive. However, such long-term transfusions will lead to the accumulation of trivalent iron and bring about an iron overload condition. To treat iron overload, the patients usually receive intravenous or subcutaneous infusion of deferoxamine mesylate (DFO) regularly. The high costs of the drug, pump, and infusion materials, as well as the side effects, limit its acceptability and utility. For this reason, we hope to be able to change the method of delivering DFO. We want to replace the traditional injection method with transdermal drug delivery system. The preliminary goal of this study is to estimate the feasibility of designing and fabricating a DFO patch by using the single-layer drug-in-adhesive transdermal drug delivery system. We expect it can enable the drug to penetrate the skin at a stable rate and reach the circulation system successfully to allow the concentration of drug reach the therapeutic window. In this research, we develop the pressure sensitive adhesives and hydrogels as the drug reservoirs and observe the release profile of DFO in the adhesives in order to develop and design transdermal patches. Because drug matrices can only contain a certain amount loading drug, the area of the designed patch is too large. The existence of Tween 80 in our pressure sensitive adhesives will enhance DFO penetrating through nude mice skin.When adding oleic acid to be penetration enhancer, the penetrating effect of DFO is enhanced. The synergistic effect of tween 80 and oleic acid in our pressure sensitive adhesives seems not very well with the ratio one to one. The pretreatment of nude mice skin with ultrasound enhance DFO penetrating through skin. But the parameters of the sonophoresis in nude mice are needed further research and development.