| Summary: | 碩士 === 國立臺灣大學 === 臨床醫學研究所 === 94 === 【Background】The associatoin between renin-angiotensin system(RAS) and the clusters of risk factors of metabolic syndrome risk were well established in literature. We hypothesized that RAS genes might be the responsible genes of metabolic syndrome and thus conducted a case-control study with this regard.
【Methods and Results】A total of 220 patients with documented metabolic syndrome and 330 controls were included. The ACE gene insertion/deletion polymorphism, the T174M, M235T, G-6A, A-20C, G-152A, and G-217A polymorphisms of the angiotensinogen gene, and the A1166C polymorphism of the angiotensin II type I receptor gene were genotyped. In single-locus analysis, ACE I/D polymorphism was significantly associated with metabolic syndrome. There was a higher I allele frequency in patient with metabolic syndrome than that of the control group(p=0.011). In multilocus haplotypes analysis, we found that three kinds of haplotypes were associated with metabolic syndrome (G-G-A-A-T-C, OR=1.73, p<0.05；G-A-A-A-C-C, OR=4.95, p<0.001；A-A-A-A-C-C, OR=5.83, p<0.05). We also found that there were more T174 alleles in the hypertension population. The odds ratios were 1.59 (95%CI 1.08 to 2.34 p=0.012). The 174M/M genotype or 174M allele were associated with a higher serum HDL level (p=0.047). The 1166C/C genotype or 1166C allele were associated with a lower serum HDL level (p=0.004).
【Conclusions】This study demonstrates the association of RAS gene polymorphisms with metabolic syndrome and may provide a rationale for clinical trials to investigate the use of ACE inhibitor or angiotensin-receptor blocker in the treatment of metabolic syndrome.
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