| Summary: | 碩士 === 國立臺灣海洋大學 === 食品科學系 === 94 === Curcumin is a natural yellow pigment. It has already been verified that curcumin has a lot of physiological activities such as antioxidation, anti-inflammation, anti-allergy, anti-tumor, anti-bacteria, anti-virus activity and anti-Alzheimer, etc. Data from clinical trials point out the systemic bioavailability of curcumin is extremely low. Furthermore, curcumin is an unstable compound that was readily oxidized by oxygen and decomposed by ultraviolet irradiation. These factors thus cause it difficult for practical applications. So the objective of this study is to apply the concepts of nanotechnology and drug delivery system to make curcumin into curcumin nanoparticles, in order to increase the stability and bioactivities of curcumin. In this study, we use silica or silica together with chitosan to encapsulate curcumin into the curcumin nanoparticle based on the silicification and biosilicification processes. Scanning electron microscope and light scattering measurement indicate that the average particle size of curcumin nanoparticles is approximately 100 nm. Curcumin encapsulated in silica nanoparticles had slightly bigger particles size than those nanoparticles encapsulated in chitosan and silica. In addition, chitosan and silica encapsulated curcumin nanoparticles had more uniform shape. Both two curcumin nanoparticles scavenge DPPH free radicals were better than curcumin, and curcumin nanoparticles chelate a small amount of ferrous ion. The anti-tumor activity of curcumin nanoparticles was significantly increased, and increased the apoptosis of tumor cells. But curcumin nanoparticles cause less DR5 expression than curcumin. Curcumin nanoparticles can increase the storage time of curcumin, and prevent the decomposition caused by ultraviolet irradiation.
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