| Summary: | 碩士 === 國立臺灣海洋大學 === 水產養殖學系 === 94 === The research made a study of the five days feeding course in tilapia with 25, 50, 75, 200 mgkg/day oxytetracycline additive feed and withdrawal time for 20 days. At day 0,1,2,3,4,5,6,7,9,13,17,21,25, examined the drug residues in fish muscle and serum. In addition, at day 0,1,2,3,4,5,6,7,9,13,17,21,25, examined non-specific immune immunological parameters and physiology parameters such as superoxide anion (O2-) production ratio,total WBC count, superoxide dismutase (SOD),glutamate oxolacetate transaminase (GOT) activity and glutamate pyruvate transaminase (GPT) activity.
The drug residues in fish muscle were highest concentratiom at day 6, after day 25, residual concentration is lower than a bulletin of government 0.1mg/kg, except for OTC of 200mg/kg/day treated . In fish serum were highest residual concentratiom at day 5 and also after day 25 the residual concentration below 0.1mg/kg in all treatment.
The result showed that O2- production ratio was decreased in all treatment, especiallyin high dose treatment, but after day 21 O2- production ratiowas return to normal level. Total WBC count, superoxide dismutase (SOD), GOT and GPT activity were no significance in all treatments.
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