Establishment of an animal model for the study of immune modulation and anti-tumor activity of Chinese herbal medicine

• Main Authors: Hsiang-Ling Huang, 黃向苓
• Other Authors: Chi-Shiun Chiang
• Format: Others
• Language: zh-TW
• Published: 2006
• Online Access: http://ndltd.ncl.edu.tw/handle/31450409459122669391

碩士 === 國立清華大學 === 生醫工程與環境科學系 === 94 === Medicinal fungi of traditional Chinese medicine have been widely used as tonic food and herbal medicine since ancient times in China. This research aimed to establish an animal system to evaluate the immunomodulation and anti-tumor activity of Chinese herbal medicine. In the literature, we were intrigued in whether Cordyceps sinensis, Poria cocos, and Schizophyllum commune could enhance the immunity and be an effective anti-tumor agent. The prostate cancer cell line, TRAMP-C1, was injected into C57BL/6J mice subcutaneously, and the water extracts of herbal medicine mentioned above were then orally administered to testify for the anti-tumor effect. Regarding the potential influences on immune function in mice, normal mice were fed with the water extracts of herbal medicine to evaluate certain targets of immunity. The results demonstrated that tumor-bearing mice treated with the water extracts of herbal medicine had a significant effect on tumor-growth delay. The mice orally administered the water extracts, in addition, activated partial immune functions, including IFN-γ, which might be an effective activator of macrophages, secreted by spleenocytes. The above suggested Cordyceps sinensis, Poria cocos, and Schizophyllum commune were efficient agents against tumor progression and served as potential immunomodulators.