| Summary: | 碩士 === 國立清華大學 === 微機電工程研究所 === 94 === Along with the trend on technology development and the knowledge evolution, here gradually comes lots of interest on how the minute objects act and how we can really apply those objects into use in many research territories, especially in biomedicine category. There are so many new research topics in biotech category, such as the optical tweezers and micro-gripper etc. They are targeted for good manipulation of cell. Since the size of what people study differs from that of traditional studies, we need the tools which have the dimension compatible with the cell size. Therefore, it comes out many new methods and applications. Recently, under the condition of developing the related researches, such as genetic engineering and single cell…etc. actively, The special feature of Micro-Electrical-Mechanical-System (MEMS), miniaturization, makes itself become one of the hot research subjects in the biomedicine technology category. This bio-chip, which is presented in this thesis and designed based on the theory of dielectrophoresis（DEP）, can function for the manipulation of cells with non-contact force in micro scale. The non-contact force has the advantage of minimizing damage possibility.
The cell manipulation via three-dimensional electric fields in this thesis allows the more precise manipulation on cells and overcomes the drawback of cell manipulation via planed electrodes. This thesis first introduces the survey of literatures, propose a novel chip design and prove the feasibility of the design concepts via the theory of DEP and the numerical analysis with CFD-RC. Furthermore, we synthesize this bio-chip system on the basis of our numerical analysis. Finally, the feasibility and the functions of this bio-chip system are verified via bio experiments.
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