| Summary: | 碩士 === 國防醫學院 === 生理學研究所 === 94 === Abstract
Modafinil (MOD) is increasingly used as a medication for elevating arousal to achieve a better performance, yet its underlying working mechanism isn't fully understood. In this study, we investigated if MOD improved attentional function and motor impulse control in five-choice serial reaction time task (5-CSRTT) and the addictive potential of MOD. The present study was designed first to investigate the possibility of MOD to enhance attentional function and impulse control under rapid eye movement sleep deprived (REMD) rats. We also interested in that if modafinil may act like a norepinephrine transporter (NET) inhibitor, thus we compared the effects between modafinil and the NET inhibitor reboxetine. Finally, cross-sensitization to apomorphine following repeated administration of MOD has been examined in this study in order to clarify the relationship between MOD and dopamine system. Our results revealed REMD reduced accuracy and increased premature in younger rats. Modafinil failed to reverse the effects of REMD and moreover, led to a lower accuracy under harder task condition (shorter stimulus and REMD). In the reboxetine side, however, led to an enhanced accuracy and decreased premature response. We also found behavioral sensitization could be occurred following subchronic treatment of MOD. In summary, MOD might impair attentional function and the capacity of impulse control, and the mechanism can not be interpreted only by the inhibition of NET. Moreover, addictive potential following repeated administration of modafinil need to be addressed based on Robinson hypothesis.
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