| Summary: | 碩士 === 國立嘉義大學 === 食品科學系研究所 === 94 === Epidemiologic studies have shown dietary fiber improved hyperlipidemia and hyperglycemia of diabetes mellitus patients. Wood ears mushroom （Auricularia polytricha）is rich in dietary fiber content. In this study, the first objective is to assess the rheological properties and antioxidant activity of polysaccharides extracted from wood ears and the next objective is to investigate the effects of wood ears polysaccharides on blood glucose and lipid in type 2 diabetes mellitus patients.
The soluble polysaccharides (43.2% total polysaccharides content ) of wood eras mushroom were obtained after extracting the fruiting body powders with hot water, sedimentating with ethanol, and then freezing dry. The rheological properties analysis revealed that apparent viscosity of polysaccharides of wood ears mushroom decreased with a increasing of shear rate at 10 -70 ℃.The flow behavior indices (n), calculated following the power law equation, of this polysaccharide were 0.52∼0.53 at the concentration of 1 mg/mL. This polysaccharide also exhibited a strong antioxidant activity, 60% of total antioxidant activity at 1 mg/mL.
Forty-two type 2 diabetes mellitus patients were radamonly divided into treatment and placebo group supplemented with 6 g capsulated wood ears mushroom polysaccharides or cellulose as placebo daily for 6 weeks, respectively. The subjects were requested to maintain orally prescription drugs. The fasting blood samples were taken after 0, 2, 4, and 6-week supplementation.
Our results showed the fasting blood glucose of the subjects treated with wood ears mushroom decreased from 208.3 mg/dL at 0-week to 146.4 mg/dL at 6-week. The HbA1c values were 9.1, 8.8, 8.8, and 8.6% after 0, 2, 4, and 6 week wood ears mushroom treatment, respectively. Wood ears mushroom treatment for 6weeks decreased triglyceride and total cholesterol levels of the subjects from 171.7 and 206.3 mg/dL to 145.1 and 177.0 mg/dL, respectively. Both HDL-C and LDL-C concentration of treatment group also decreased from 49.6 and 122.3 mg/dL to 46.7 and 101.4 mg/dL after 6 weeks, respectively. However, SOD and TAS were not significantly affected.
In conclusion, our data demonstrated that the hypoglycemic, hypolipidemic, and hypocholesterolemic effects of wood ears mushroom on type 2 diabetes mellitus patients. Thus, dietary supplementation with wood ears mushroom is suggested for type 2 DM patients to prevent the risk of future complications.
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