Mootprinting : Identifying transcription factor binding targetgenes by phylogenetic footprinting

• Main Authors: Jyh-Huang Torng, 童志煌
• Other Authors: Jorng-Tzong Horng
• Format: Others
• Language: en_US
• Published: 2006
• Online Access: http://ndltd.ncl.edu.tw/handle/gf3rn3

碩士 === 國立中央大學 === 資訊工程研究所 === 94 === The analyses of gene expression provide lots of possible transcription factor regulated gene group. It is proven that phylogenetic footprinting method can help to identify transcription factor binding sites. Our work develops a system that combines the motif searching and phylogenetic footprinting. After a motif and gene group is submitted, the system is able to evaluate statistics of motifs appearance in whole genes and a set of genes upstream conserved region between human and mouse. A transcription factor-target gene group was used to test the proposed system. The results present the system can distinguish transcription factor--target gene group from random gene groups. By comparing motif distribution between whole genes and gene group, the proposed system is able to help biologists identify possible transcription factor regulated genes groups form groups of gene expression.