Wortmannin ameliorates Zinc oxide nanoparticles-induced cytotoxicity and morphological abnormality in NIH-3T3 cell

• Main Authors: Shi-Wen Chiu, 邱士紋
• Other Authors: Guewha Steven Huang
• Format: Others
• Language: zh-TW
• Published: 2006
• Online Access: http://ndltd.ncl.edu.tw/handle/12877130418225728554

碩士 === 國立交通大學 === 奈米科技研究所 === 94 === Nano-sized materials are often greeted for their extraordinary electronic, light-emitting, and catalytic properties. But their unique physical characteristics raise concerns that nanometer scale of metals, ceramics, and organics could prove uniquely toxic as well. Nano-sized particles could be environmental pollution or even the loss of human life. In this study, we investigated the cytotoxicity among different size of Zinc Oxide Nanoparticles in Mouse fibroblast cell (NIH-3T3). We found that the viability and morphology of NIH-3T3 cell were affected by incorporation of ZnO nanoparticle. This effect was size and dose-dependent. Application of the cytotoxicity and morphological abnormality of NIH-3T3 cell were by means of Wortmannin.