The Study of DEP-based Microsorter for Multiple/Continuous Particle Sorting

博士 === 國立成功大學 === 航空太空工程學系碩博士班 === 94 ===  This study is an attempt to research on microsorters by incorporating Dielectrophoresis (DEP) theories. The research was inspired by the impressing need, in the field of biotechnology and medical applications, of the ability to sort out the cells of intere...

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Bibliographic Details
Main Authors: Hung-Ying Chen, 陳鴻瑩
Other Authors: Fei-Bin Hsiao
Format: Others
Language:en_US
Published: 2006
Online Access:http://ndltd.ncl.edu.tw/handle/13415711414207397371
Description
Summary:博士 === 國立成功大學 === 航空太空工程學系碩博士班 === 94 ===  This study is an attempt to research on microsorters by incorporating Dielectrophoresis (DEP) theories. The research was inspired by the impressing need, in the field of biotechnology and medical applications, of the ability to sort out the cells of interest from the sample mixture. The study started with related literature review regarding DEP force and microsorting mechanism. It was confirmed that DEP, in biotechnology, serves as an appropriate mechanism in manipulating and sorting cells for no risk to cause damage to the sample.  Based on the DEP theories, an innovated microsorting design was proposed in this study. The design employed DEP force to both focus and continuously sort the particles, through the contraction electrode as the first section and parallel electrode with different length as the second one. The designed model and procedures were carried out and verified through numerical simulation (CFD-ACE+) and experiment.  The simulation and experimental results were reported and compared. The experiment results are agreement with the simulation results. Most importantly, the research finding indicated that the proposed design of microsorter was proved to be feasible, appropriate, and unique. The study concluded with the contribution to the field of microsorting and the implication for further research.