Synthesis and Antiproliferative Evaluation of Furocarbazole, Benzimidazoisoquinolone, and β-Carboline Derivatives

• Main Authors: Bo-Sheng Lin, 林柏勝
• Other Authors: 曾誠齊
• Format: Others
• Language: zh-TW
• Published: 2006
• Online Access: http://ndltd.ncl.edu.tw/handle/12381676558003319922

碩士 === 高雄醫學大學 === 藥學研究所碩士班 === 94 === Synthesis and antiproliferative evaluation of furocarbazole, benzimidazoisoquinolone, and β-carboline derivatives with the structural characteristics of DNA-intercalator are described. The results of this study indicate that the cytotoxic effect depends on the basic side chains inserted in the planar nucleus of furocarbazole, and benzimidazoisoquinolone. The propanylamine substituted of furocarbazole derivatives (11d, 12d, 13d), which show the most significant antiproliferative activity on the growth of MCF-7, NCI-H460, and SF-268 at a concentration of 4 μg/mL. The alkylamino substituted side chains of benzimidazoisoquinolone derivatives might facilitate the antiproliferative activity, 18c has particular effect. However, the substituents at position-1 of β-carboline derivatives displayed modest antiproliferative activity.