| Summary: | 碩士 === 高雄醫學大學 === 藥學研究所碩士在職專班 === 94 === Nicardipine HCl is a calcium channel antagonist. It is used in the treatment of hypertension, angina pectoris, reduction the dangerous of stroke and death. Orally dissolving strips are solid dosage forms that dissolved completely in the oral cavity and easy to take without water. When such strips are placed in the oral cavity, saliva quickly penetrates into the strips to cause rapidly strips erosion.
A statistical factorial experimental design was used to optimize the formulation of orally dissolving Nicardipine HCl strips. A 32 experimental design was employed to evaluate the disintegration time of the orally dissolving strips; subsequent data was compared using analysis of variance (ANOVA). The characterization of the orally dissolving strips was studied, such as disintegration time, uniformity content of the strips, and in-vitro release test. The interaction between Nicardipine HCl and excipients were studied in the solid state by differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FT-IR).
The experimental design study illustrated that the concentration of binders had significant effect on the disintegration time. The results of DSC and FTIR spectra indicated that some interaction between Nicardipine HCl and excipients. An optimum formulation showed a shortest disintegrating time of 13.18 s.
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