Evaluating the effect of medication on the UV transmission by using a skin model

• Main Authors: Shih-Wen Su, 蘇世文
• Other Authors: Cheng-Lun Tsai
• Format: Others
• Language: zh-TW
• Published: 2006
• Online Access: http://ndltd.ncl.edu.tw/handle/15108922818546875347

碩士 === 中原大學 === 醫學工程研究所 === 94 === Psoriasis is a non-contagious, chronic, and recurrent skin disorder which appears as inflamed lesions and is covered with silvery scale. Up to now, psoriasis still cannot be completely cured, but can only be controlled by treatment. Narrow band ultraviolet-B phototherapy and psoralen with ultraviolet-A photochemotherapy have become popular treatment of psoriasis because of their long recurrent period. The dose of ultraviolet entering skin tissue is determined by the absorption of medication and the scattering on skin surface. In order to measure ultraviolet transmission through applied medication, an acrylic skin model was made in this study to mimic the optical scattering property of skin surface. The results show that ultraviolet transmission increases only when a small amount of translucent medication is applied. This is due to the reduction of surface scattering by matching the refraction index between skin and medication. When more medication is applied, the ultraviolet transmission decreases again because of the absorption by medication. By using the model with skin surface profile, the ultraviolet dose can be more accurately estimated. The amount of medication to increase the ultraviolet transmission in phototherapy should be carefully controlled.