| Summary: | 碩士 === 中原大學 === 醫學工程研究所 === 94 === Psoriasis is a non-contagious, chronic, and recurrent skin disorder
which appears as inflamed lesions and is covered with silvery scale. Up
to now, psoriasis still cannot be completely cured, but can only be
controlled by treatment. Narrow band ultraviolet-B phototherapy and
psoralen with ultraviolet-A photochemotherapy have become popular
treatment of psoriasis because of their long recurrent period.
The dose of ultraviolet entering skin tissue is determined by the
absorption of medication and the scattering on skin surface. In order to
measure ultraviolet transmission through applied medication, an acrylic
skin model was made in this study to mimic the optical scattering
property of skin surface. The results show that ultraviolet transmission
increases only when a small amount of translucent medication is applied.
This is due to the reduction of surface scattering by matching the
refraction index between skin and medication. When more medication
is applied, the ultraviolet transmission decreases again because of the
absorption by medication.
By using the model with skin surface profile, the ultraviolet dose can
be more accurately estimated. The amount of medication to increase the
ultraviolet transmission in phototherapy should be carefully controlled.
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