Effects of Different Estrogen Receptor Agonists on Rotenone-induced Parkinsonism in Rats

• Main Authors: Yu-Jei Lei, 雷玉潔
• Other Authors: 陳卓昇
• Format: Others
• Language: zh-TW
• Published: 2006
• Online Access: http://ndltd.ncl.edu.tw/handle/77354310720068516396

碩士 === 中國醫藥大學 === 醫學研究所碩士班 === 94 === The aim of this study was to investigate the neuroprotective effect of selective estrogen receptor (ER) agonists on the nigro-striatal system. Parkinsonism was induced in ovariectomized rats by treatment of rotenone via subcutaneous osmotic minipump (3 mg/kg/day) for 2 weeks. These rats simultaneously received daily injection of estradiol (10 ug/kg) or selective estrogen receptor (ER) agonists （1 mg/kg）. Locomotor activities were observed before and 2 weeks after rotenone treatment. The results revealed that ER alpha agonist improved the locomotor activities in rotenone-treated rats. Tyrosine hydroxylase (TH) levels in substantia nigra were not different among treatment groups. Levels of Mn-SOD and Bcl2 also were not altered. Cu/Zn-SOD was decreased by rotenone treatment.However, ER agonist failed to prevent the reduction. These data suggest that ER alpha may be involved in the neuroprotective effects of estrogen on nigro-striatal system.