Age and Gender Influences 18F-deoxyglucose (FDG) metabolism in normal Healthy Examination Study --A PET study

• Main Authors: Ming-Cheng Wei, 魏銘政
• Other Authors: Chia-Hung Kao
• Format: Others
• Language: zh-TW
• Published: 2006
• Online Access: http://ndltd.ncl.edu.tw/handle/58973379959005966914

碩士 === 中國醫藥大學 === 臨床醫學研究所碩士班 === 94 === In the passes, when we make the brain semi-quantity analysis, We frequently needs to circle the interest area (ROI, region of interest), then surveys it to count the value. Then uses the statistical software processing empirical datum afterwards, for example SAS, SPSS, or use Microsoft Excel to make the material statistics, compared with difference. But frequently because of the different person circle the different position and size , is extremely easy to create the personal error, as well as only can obtain the change in the material data, compared with does not have the integrity (Hall et al., 1991; Hibbard et al., 1987; Zhaoet al., 1995, 1996).Therefore the SPM software then breeds lives. In functional brain image instrument and so on SPECT/PET and fMRI, to gains the cerebrum space image and the material analysis software, SPM (Statistical Parametric Mapping, Friston 1991, The Wellcome Department of Imaging Neuroscience Functional Imaging Laboratory) is the most world cognition department of neurology scientist is quoted a number of times most set of analyses software in the scientific periodical (http://www.fil.ion.ucl.ac.uk/spm/). SPM (Friston et al., 1991,1994 ; Poline et al., 1995; Worsley et al., 1992), is the union the trying image and the statistical method software. It is comparison the difference statistical value in the image between the voxel and voxel, It generally may be supposed to use in nuclear medical radiography PET/SPECT perhaps the function radiography (fMRI) the brain function research. During the past paper experience, we saw the use of brain function nuclear magnetic resonance (fMRI), the single photon emission computer scan (SPECT) .It inspect the regional brain blood current capacity so as to discuss the functional localization which the different brain region represents (brain mapping) We set up cases who accept the PET (Positron Emission Tomography) in healthy exam in the hospital by the Chinese medicine university, after excluded the patient which has the whole body system disease. Divides cases into the male it to be smaller than 60 years old, the male is bigger than 60 years old, the female is smaller than 60 years old, as well as the female is bigger than 60 years old of altogether four groups, each 25 people, processing intersect analyzes of his/her brain metabolism whether has basic difference. Glucose is the most important material in brain metabolism .The Positron Emission Tomography (PET) use has the radioactive glucose, the affiliation by it in the brain absorption condition, with represents its partial region metabolism function .So as to recognized its functional localization. After excluded the patient which has the systematic disease, carries on the Positron Emission Tomography .Then use the SPM software pre-process of image material as segmentation ,normalization and smoothing. Chooses the way afterwards which we must count, makes Two-sample the T-Test pattern, chooses this experimental goal subject in the trying image, establishes the P value to be smaller than 0.05 as statistics result . Then demonstrate in Talairach space (dark spot), We may know had any problem in the brain region. May see by the result, above the synthesis findings conclusion leaves, the healthy adult''s brain glucose metabolism, has basic different in the sex and the age. Speaking of the male, the young male is intense in the comprehension faculty (BA24) and the mood response (BA47). Speaking of the female, the young female is intense in the mood response (BA38,47). But a young male has a better performance to the visual movement (BA19) and the memory, language (BA37) then younger female.