Study on anti-nociceptive, anti-inflammatory and anti-oxidant effects of Dendrobium crumenatum SW., Dendrobium moniliforme (L.) SW. and Ephemerantha lonchophylla HUNT & SUMMERH.

• Main Authors: Sung-Ping Chen, 陳松賓
• Other Authors: Wen-Huang Peng
• Format: Others
• Language: zh-TW
• Published: 2006
• Online Access: http://ndltd.ncl.edu.tw/handle/48769181219143314765

碩士 === 中國醫藥大學 === 中國藥學研究所 === 94 === In the present study, we investigated the anti-nociceptive effect of ethanol extracts of Dendrobium crumenatum (DCEtOH), Dendrobium moniliforme (DMEtOH) and Ephemerantha lonchophylla (ELEtOH) by acetic acid-induced writhing response, formalin test, and the anti-inflammatory effect by λ-carrageenin-induced paw edema. We also detected the changes in the activities of SOD, GSH-Rx and GSH-Px of liver to investigate the anti-oxidant of DCEtOH, DMEtOH and ELEtOH. The results shown that DCEtOH and DMEtOH significantly inhibited the acetic acid-induced writhing response. DCEtOH significantly inhibited formalin-induced licking time during the early phase and late phase. DMEtOH significantly inhibited formalin-induced licking time during the late phase. DCEtOH, DMEtOH and EL EtOH significantly decreased the λ-carrageenin-induced paw edema. DC EtOH and EL EtOH significantly increased SOD and GSH-Px activities. DC EtOH, DMEtOH and EL EtOH significantly increased GSH-Px activities. The contents of total alkaloids was DCEtOH > DMEtOH > ELEtOH. The results suggested that DCEtOH and DMEtOH possessed anti-nociceptive and anti-inflammatory effects. EL EtOH possessed anti-inflammatory effect. The anti-inflammatory mechanism of DC EtOH and EL EtOH may be related to the increase in the SOD and GSH-Px activities. The anti-inflammatory mechanism of DMEtOH may be related to the increase in the GSH-Px activities. The anti-nociceptive, anti-inflammatory and anti-oxidant effects of DCEtOH, DMEtOH and EL EtOH effects may be related to the changes in the contents of total alkaloids.