Synthesis of PTMC-b-PCL Copolymers and Their Micelles Characterizations

• Main Authors: Chia-Sheng Lai, 賴佳昇
• Other Authors: Fang-Chyou Chiu
• Format: Others
• Language: zh-TW
• Published: 2006
• Online Access: http://ndltd.ncl.edu.tw/handle/72715634263142481684

碩士 === 長庚大學 === 化工與材料工程研究所 === 94 === A series of amphiphilic diblock PTMC-block-PCL copolymers were synthesized by ring-opening polymerization from trimethylene carbonate (TMC) and ε-caprolactone (ε-CL) in the presence of SnOct2 catalyst. The prepared samples were characterized by DSC、1H NMR and GPC techniques. According to DSC results, when the ε-CL content of diblock copolymer increased, the melting temperature (Tm) increased, but the glass-transition temperature (Tg) decreased .The Oil/Water emulsion method was employed to prepare the micelles from the copolymers. The characteristics of the micelles in an aqueous phase were investigated by fluorescence spectrum、ultraviolet/visible spectrum、transmission electron microscope and dynamic light scattering technique. The diblock copolymers with various pendant groups formed micelles in the aqueous phase with critical micelle concentrations（CMCs）in the range from 2.23 mgL-1 to 14.6 mgL-1. The efficiency of drug entrapment for the micelles was 11.6% ~ 54.6%. The micelles basically exhibited spherical or core-and-shell texture. After hydrogenation, the critical micelle concentrations and drug entrapment efficiency of the micelles increased.