Synthesis of galactose-encapsulated quantum dotas specific carrier for targeting hepatoma cell

• Main Authors: Yu-Fang Lo, 羅玉芳
• Other Authors: Chun-Cheng Lin
• Format: Others
• Language: zh-TW
• Published: 2006
• Online Access: http://ndltd.ncl.edu.tw/handle/35479877339565384826

碩士 === 國立中正大學 === 化學所 === 94 === Nanoparticles are colloidal particles of size ranging from 10 to 100 nm , they are currently employed in various fields of life science. The semiconductor nanocrysyals, also called quantum dots (QDs) have unique photochemical and photophysical properties and serve as luminescence probes for many biological and biomedical applications. In this thesis, we synthesized the water-soluble galactose-capped CdSe/ZnS quantum dots, and demonstrated the receptor-mediated delivery of galactose-capped quantum dot into asialoglycoprotein-receptor-positive cell such as HepG2 cells. Receptor-mediated delivery was confirmed by comparison the uptake of these QDs with asialoglycoprotein-receptor-negative cells such as HeLa cells. The results showed that the HepG2 cells uptook more galactose –capped QDs than those HeLa cells. Theses result encourage us to improve our QDs as specific carriers to deliver anticancer drug or MRI contrast agents toward liver cancer cell in future.