| Summary: | 碩士 === 國立陽明大學 === 公共衛生研究所 === 93 === The Risk Factors of Posttraumatic Stress Disorder and Life Quality among Patients after Bone Marrow Transplantation/Peripheral Blood Stem Cell Transplantation
Objective：To investigate the mental status, prevalence rate and risk factors of transplantation related posttraumatic stress disorder (PTSD) and life quality of patients after bone marrow transplantation(BMT)/peripheral blood stem cell transplantation(PBSCT)
Methods:：
This study was hospital based and cross-sectional design. The data was collected from April 2004 to March 2005 through medical records and interview. The subjects were patients who received BMT or PBSCT in Taipei Veterans General Hospital, older than 18 years old and still survived. The investigator asked the patients about their will in joining the study by telephone. The patients were interviewed by a psychiatrist using MINI diagnostic interview and also filled self-rating questionnaires including Hospital Anxiety and Depression Scale, Impact of Event Scale, SF-36. All data was analyzed with SPSS 11.5 software.
Results：332 patients received BMT or SCT in Taipei Veterans General Hospital from April 1997 to August 2004. Among them, 121 patients passed away, 27 patients were younger than 18 years old, 54 patients could not be reached. 123 patients completed the study by either face-to-face interview or telephone interview. The mean age was 40.8 years old. The main diagnoses for transplantation were leukemia or lymphoma. The prevalence rate of transplantation related PTSD was 13%. Almost half of the patients with PTSD were also comorbid with major depression. Significant risk factors from univariate analysis for developing transplantation related PTSD were gender, economic status, past traumatic experience and current performance status. Multiple logistic regression showed that female gender, very poor economic status and lower performance status were risk factors for developing transplantation related PTSD. The patients with PTSD scored lower for each domain of SF-36 life quality except body pain, and also were more anxious, more depressive, had more fatigue feeling, poorer sleep quality and more withdrawal social life.
Conclusions：After BMT/SCT, patients could possibly suffer from transplantation related PTSD, especially female gender, very poor economic status and lower performance status. Their life qualities were also impaired by PTSD. Except follow up of patients’ physical condition, clinicians should take attention to their mental health.
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