Synthesis and Cytotoxicity of Cantharidinimide Dimers and Imide Analogues

• Main Authors: Yu-Huan Lee, 李毓寰
• Other Authors: Pen-Yuan Lin
• Format: Others
• Language: zh-TW
• Published: 2005
• Online Access: http://ndltd.ncl.edu.tw/handle/44565212090029989950

碩士 === 臺北醫學大學 === 藥學系 === 93 === Mylabris phalerata, Meloidae family of Coleoptera, has been known since antiquity to produce a potent toxic defensive agent, known as cantharidin (exo,exo-2,3-dimethyl-7-oxabicyclo [2.2.1] heptane-2,3- dicarboxylic anhydride), but well-known as Spanish Fly. In the past, Cantharidin has used as anticancer, herbicidal, pesticide and treatment of hepatic carcinoma and molluscum contagiosum activities.We used cantharidin and serious of diaminoalkane as starting materials, by heating 200℃ in sealed tube to form various cantharidinimide dimer. The other hand, we utilized various N-activated aziridine derivatives as starting materials, reacted with cantharidinimide and different imide analogous to obtain serial derivatives. All of the products were measured by 1H-NMR, IR, High-resolution mass spectrometry. In addition, we evaluated these compounds in cytotoxicity.