| Summary: | 碩士 === 慈濟大學 === 醫學研究所 === 93 === Oral cancer is the seventh leading cancer, and the fourth common cancer in male in Taiwan. Oral cancer is a complex disease; which could be affected by both genetic and environmental factors as other cancers. Some of epidemiological studies indicate that cigarette smoking, alcohol drinking and betel nut chewing are associated with carcinogenesis of oral cancer. Other studies, however, indicate that not all of these exposures result in oral cancer, neither is the disease necessarily dose-response-related. Therefore, genetic predisposition of subjects might be one of important factors on this phenomenon.
Plasminogen activation system, which mediates extracellular proteolysis is considered as an important physiological mechanism involved in tissue remodeling and thrombolysis as well as in tumor invasion and metastasis. Plasminogen activator inhibitor-1 (PAI-1), one of factors in urokinase-type plasminogen activator system, now is regarded as important prognostic factor for different cancers, such as colorectal cancer, endometrial cancer and cancer in head or neck.
We investigated the relations among oral cancer, environmental factors (smoking, alcohol drinking, and betel nut chewing), and the variation in the deletion/insertion (4G/5G) promoter polymorphism of the PAI-1 gene in 104 oral cancer patients and 143 healthy controls in eastern Taiwan. The 4G/5G polymorphism was determined by PCR-RFLP (polymerase chain reaction- restriction fragment length polymorphism). The results indicated that PAI-1 gene polymorphism is not associated with the risk of oral cancer. However, there is an association between smokers, betel nut chewers who present the PAI-1 gene 5G/5G genotype and oral cancer (for smoker, adjusted OR=3.20, 95% CI=1.23-8.35; for areca quid chewer, adjusted OR=3.01, 95% CI=1.10-8.34). Thus, the PAI-1 gene 5G/5G genotype appears to be a risk factor of oral cancer in smokers and betel nut chewer.
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