| Summary: | 碩士 === 樹德科技大學 === 應用設計研究所 === 93 === It has been a long history since liposome as a drug carrier was applied in the medical field. However, it is a brand new concept to the cosmetic industry just in the recent years. Due to the similarity of chemical structure between liposomes and human skin, it is easier for liposome to carry an active agent that is necessary for skin cells and help the agent to penetrate through skin deeply.
The study was trying to create a kind of liposome that will carry Magnesium Ascorbyl Phosphate (MAP) as an active agent by using two equipments - the ultra homogenizer and the Microfluidizer. Three different kinds of samples are made. One is created by the ultra homogenizer with rotation speed 19,000, and duration time is 5 minutes. The other two is made by the Microfluidizer with pressure setting at 700 bar. One of two is made with 10 cycling times. Another is 20 cycling times. Once these prototypes are created in the lab, they will be measured by size and drug entrapment efficiency. Also the liposomes will be evaluated with stability and transdermal permeation in vitro via dissolution test.
The final result indicates that the size of the liposome is about 0.5~1.1um. The smallest one, whose size is about 515 nanometers, was made by the Microfluidizer with 20 cycling times. Although the size of all of three samples does not reach nanometer, it is proved that liposome is capable of carrying MAP as its content. Our results also shows that the drug entrapment efficiency is about 43~52%. Liposome was made by the ultra homogenizer has higher entrapment efficiency. In the safety test, it shows that no sign of allergy. And the dissolution test indicates that MAP was released from the liposome at the same speed, and there is no significant difference among the three samples after 24 hours.
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