Enzymatic synthesis of Cinnamic Acid Derivatives

• Main Authors: Chia-hsiu Lee, 李嘉修
• Other Authors: I-hsu Chu
• Format: Others
• Language: en_US
• Published: 2005
• Online Access: http://ndltd.ncl.edu.tw/handle/24397101373491962989

碩士 === 國立臺灣科技大學 === 化學工程系 === 93 === Ferulic acid (4-hydroxy 3-methoxy cinnamic acid), which occurred naturally in many plants, has been shown to possess photoprotective, antioxidant, antitumor and hypertensive activities. Octyl methoxycinnamate (OMC) is the most widely used non-allergic sunscreen agent in the market. Most literatures reported low conversion and long reaction time in the syntheses of ethyl ferulate and OMC. In his study, Novozym 435 was selected as the catalyst for the syntheses of ethyl ferulate from ferulic acid and ethanol, and OMC from 4-methoxycinnamic acid and 2-ethyl hexanol. Parameters that affect the conversion of these reactions as well as the reusability of Novozym 435 were systematically investigated.