| Summary: | 碩士 === 國立臺灣大學 === 醫事技術學研究所 === 93 === The object of this study is focused on the inhibitory effect of proplis on viral infectivity. It has been reported that propolis possessed inhibitory effects on herpes simplex virus type 1 (HSV-1) and rhinovirus. In this report, the HSV-2 and enteroviruses which belong to the same family of picornviruses as rhinovirus were used as the subjects to evaluate the inhibitory effect of propolis. The propolis from Taiwan or France were extracted with water or ethanol and used for subsequent in vitro study. The results showed that the minimal inhibitory concentration for HSV-1 and HSV-2 were 0.5% for water extracted propolis and 0.1% for ethanol extracted propolis. No inhibitory effect on poliovirus type 1, poliovirus type 2 or poliovirus type 3 were observed. The results of timing study revealed that the maximal inhibitory effect on HSV-1 and HSV-2 were found at 2 hours after propolis application.The non-lipid-enveloped virus, enterovirus, has no response to propolis treatment even at the 1% concentration of ethanol extracted propolis. In addition, at 0.1% concentration, propolis from Frence has distinct inhibitory effect to HSV-1. Propolis from Taiwan only showed inhibitory effect at 0.5% concentration. The mechanisms of this inhibitory effect to HSV need to be further studied in the future.
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