Part I: Liquid-Phase Combinatorial Synthesis of 1,4-Benzodiazepine-2,5-diones as Endothelin Receptor AntagonistsPart II: Synthesis of Biosynthetic Intermediate Analogues of Spinosyn A: An Approach to Investigation of Polyketide Combinatorial Biosynthesis

Part I: Liquid-Phase Combinatorial Synthesis of 1,4-Benzodiazepine-2,5-diones as Endothelin Receptor AntagonistsPart II: Synthesis of Biosynthetic Intermediate Analogues of Spinosyn A: An Approach to Investigation of Polyketide Combinatorial Biosynthesis

博士 === 國立臺灣大學 === 化學研究所 === 93 === Part I: Liquid-Phase Combinatorial Synthesis of 1,4-Benzodiazepine-2,5-diones as Endothelin Receptor Antagonists A series of 1,4-benzodiazepine-2,5-diones are prepared by using 2-nitrobenzoyl chloride as a synthetic equivalent of anthranilic acid in solution-phas...

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Main Authors: Ming-Fu Cheng, 鄭名富
Other Authors: Jim-Min Fang
Format: Others
Language:zh-TW
Published: 2005
Online Access:http://ndltd.ncl.edu.tw/handle/17163598195047816342
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spelling ndltd-TW-093NTU050650192015-12-21T04:04:54Z http://ndltd.ncl.edu.tw/handle/17163598195047816342 Part I: Liquid-Phase Combinatorial Synthesis of 1,4-Benzodiazepine-2,5-diones as Endothelin Receptor AntagonistsPart II: Synthesis of Biosynthetic Intermediate Analogues of Spinosyn A: An Approach to Investigation of Polyketide Combinatorial Biosynthesis 第一部份：液相組合式合成1,4-Benzodiazepine-2,5-diones作為內皮素受體拮抗劑第二部份：SpinosynA生合成中間體類似物之合成：一個探討Polyketide組合式生物合成的研究方法 Ming-Fu Cheng 鄭名富 博士 國立臺灣大學 化學研究所 93 Part I: Liquid-Phase Combinatorial Synthesis of 1,4-Benzodiazepine-2,5-diones as Endothelin Receptor Antagonists A series of 1,4-benzodiazepine-2,5-diones are prepared by using 2-nitrobenzoyl chloride as a synthetic equivalent of anthranilic acid in solution-phase. The derivatives have appropriate substituents at N1-, N4- and C3-positions to mimic the amino acid residues of Try-13, Phe-14, and Asp-18 in endothelin-1. Upon the successful solution-phase synthesis of 1,4-benzodiazepine-2,5-diones, we also explore a liquid-phase combinatorial synthesis to construct a library of 1,4-benzodiazepine-2,5-diones. The library is established by using the starting materials of Jim-Min Fang 方俊民 2005 學位論文 ; thesis 423 zh-TW
collection NDLTD
language zh-TW
format Others
sources NDLTD
description 博士 === 國立臺灣大學 === 化學研究所 === 93 === Part I: Liquid-Phase Combinatorial Synthesis of 1,4-Benzodiazepine-2,5-diones as Endothelin Receptor Antagonists A series of 1,4-benzodiazepine-2,5-diones are prepared by using 2-nitrobenzoyl chloride as a synthetic equivalent of anthranilic acid in solution-phase. The derivatives have appropriate substituents at N1-, N4- and C3-positions to mimic the amino acid residues of Try-13, Phe-14, and Asp-18 in endothelin-1. Upon the successful solution-phase synthesis of 1,4-benzodiazepine-2,5-diones, we also explore a liquid-phase combinatorial synthesis to construct a library of 1,4-benzodiazepine-2,5-diones. The library is established by using the starting materials of
author2 Jim-Min Fang
author_facet Jim-Min Fang
Ming-Fu Cheng
鄭名富
author Ming-Fu Cheng
鄭名富
spellingShingle Ming-Fu Cheng
鄭名富
Part I: Liquid-Phase Combinatorial Synthesis of 1,4-Benzodiazepine-2,5-diones as Endothelin Receptor AntagonistsPart II: Synthesis of Biosynthetic Intermediate Analogues of Spinosyn A: An Approach to Investigation of Polyketide Combinatorial Biosynthesis
author_sort Ming-Fu Cheng
title Part I: Liquid-Phase Combinatorial Synthesis of 1,4-Benzodiazepine-2,5-diones as Endothelin Receptor AntagonistsPart II: Synthesis of Biosynthetic Intermediate Analogues of Spinosyn A: An Approach to Investigation of Polyketide Combinatorial Biosynthesis
title_short Part I: Liquid-Phase Combinatorial Synthesis of 1,4-Benzodiazepine-2,5-diones as Endothelin Receptor AntagonistsPart II: Synthesis of Biosynthetic Intermediate Analogues of Spinosyn A: An Approach to Investigation of Polyketide Combinatorial Biosynthesis
title_full Part I: Liquid-Phase Combinatorial Synthesis of 1,4-Benzodiazepine-2,5-diones as Endothelin Receptor AntagonistsPart II: Synthesis of Biosynthetic Intermediate Analogues of Spinosyn A: An Approach to Investigation of Polyketide Combinatorial Biosynthesis
title_fullStr Part I: Liquid-Phase Combinatorial Synthesis of 1,4-Benzodiazepine-2,5-diones as Endothelin Receptor AntagonistsPart II: Synthesis of Biosynthetic Intermediate Analogues of Spinosyn A: An Approach to Investigation of Polyketide Combinatorial Biosynthesis
title_full_unstemmed Part I: Liquid-Phase Combinatorial Synthesis of 1,4-Benzodiazepine-2,5-diones as Endothelin Receptor AntagonistsPart II: Synthesis of Biosynthetic Intermediate Analogues of Spinosyn A: An Approach to Investigation of Polyketide Combinatorial Biosynthesis
title_sort part i: liquid-phase combinatorial synthesis of 1,4-benzodiazepine-2,5-diones as endothelin receptor antagonistspart ii: synthesis of biosynthetic intermediate analogues of spinosyn a: an approach to investigation of polyketide combinatorial biosynthesis
publishDate 2005
url http://ndltd.ncl.edu.tw/handle/17163598195047816342
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