Part I: Liquid-Phase Combinatorial Synthesis of 1,4-Benzodiazepine-2,5-diones as Endothelin Receptor AntagonistsPart II: Synthesis of Biosynthetic Intermediate Analogues of Spinosyn A: An Approach to Investigation of Polyketide Combinatorial Biosynthesis
博士 === 國立臺灣大學 === 化學研究所 === 93 === Part I: Liquid-Phase Combinatorial Synthesis of 1,4-Benzodiazepine-2,5-diones as Endothelin Receptor Antagonists A series of 1,4-benzodiazepine-2,5-diones are prepared by using 2-nitrobenzoyl chloride as a synthetic equivalent of anthranilic acid in solution-phas...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2005
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| Online Access: | http://ndltd.ncl.edu.tw/handle/17163598195047816342 |
| Summary: | 博士 === 國立臺灣大學 === 化學研究所 === 93 === Part I: Liquid-Phase Combinatorial Synthesis of 1,4-Benzodiazepine-2,5-diones as Endothelin Receptor Antagonists
A series of 1,4-benzodiazepine-2,5-diones are prepared by using 2-nitrobenzoyl chloride as a synthetic equivalent of anthranilic acid in solution-phase. The derivatives have appropriate substituents at N1-, N4- and C3-positions to mimic the amino acid residues of Try-13, Phe-14, and Asp-18 in endothelin-1.
Upon the successful solution-phase synthesis of 1,4-benzodiazepine-2,5-diones, we also explore a liquid-phase combinatorial synthesis to construct a library of 1,4-benzodiazepine-2,5-diones. The library is established by using the starting materials of
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