Remote and local activation of gene expression using DNA-gold nanodors conjugates by infrared irradiation

• Main Author: 林燕萍
• Other Authors: 陳家俊
• Format: Others
• Language: zh-TW
• Published: 2005
• Online Access: http://ndltd.ncl.edu.tw/handle/52728341975927058359

碩士 === 國立臺灣師範大學 === 化學系 === 93 === The precious control of the biomolecule releasing on specific localizations of the cell is the key issue for further bio-medical application of bio-functionalized nanomaterials. Herein, we demonstrate that DNA functionalized gold nanorods can be used as a gene carrier. Under the infrared radiation, the structural transformation of gold nanorods into spherical gold nanoparticles results in the realses of DNA in the cells. The cells with the radiation generate the gene expression locally. Our results suggest that the new gene activated technigue using DNA functionalized gold nanorods as a carrier is applicable for gene therapy for specific cells.