Synthesis and Application of Chiral Macrocyclic Polydentate Ethers

• Main Authors: Ya-Ching Chen, 陳雅菁
• Other Authors: Thomas Y. R. Tsai
• Format: Others
• Language: zh-TW
• Published: 2005
• Online Access: http://ndltd.ncl.edu.tw/handle/52940316381435561216

碩士 === 國立東華大學 === 化學系 === 93 === Macrocyclic polydentate ethers form the complex selectively with different cations. According to this property, chiral macrocyclic polydentate ethers were used as catalysts for several asymmetric reactions,such as Michael addition, aldol reaction, epoxidation, phase-transfer catalysts and etc. This thesis describes in detail the synthesis of chiral ligands and its application. Commercial available chemical—(S)-(-)-Methyl lactate as the starting material to prepared chiral intermediate compound (10),followed by SN2 reaction with different dihydroxy or diamine molecules to produce a variety of chiral macrocyclic polydentate ethers. Finally, optimize the enantioselectivity by means of different solvents and temperatures.