Enaantioselective Synthesis of Pipecolic Acids

Enaantioselective Synthesis of Pipecolic Acids

碩士 === 國立中央大學 === 化學研究所 === 93 === The synthesis of 57 is based on the chiral oxazinone 59 as a chiral glycine enolate synthon. Asymmetric alkylation of 59 with 1,4-diiodobutane, deprotection and cyclization gave the 4-phenylhexahydropyrido[2,1-c][1,4] oxazin-1-one. Both enantiomers of pipecolic aci...

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Main Authors: Shin-Yi Hung, 洪欣怡
Other Authors: Duen-Ren Hou
Format: Others
Language:zh-TW
Published: 2005
Online Access:http://ndltd.ncl.edu.tw/handle/57848743957042874656
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spelling ndltd-TW-093NCU050650522015-10-13T16:31:55Z http://ndltd.ncl.edu.tw/handle/57848743957042874656 Enaantioselective Synthesis of Pipecolic Acids 合成具有光學活性之六氫菸鹼酸(Pipecolicacid) Shin-Yi Hung 洪欣怡 碩士 國立中央大學 化學研究所 93 The synthesis of 57 is based on the chiral oxazinone 59 as a chiral glycine enolate synthon. Asymmetric alkylation of 59 with 1,4-diiodobutane, deprotection and cyclization gave the 4-phenylhexahydropyrido[2,1-c][1,4] oxazin-1-one. Both enantiomers of pipecolic acid and 2-alkyl pipecolic acids were prepared by the epimerization or the second alkylation of 58 followed by hydrogenation. Duen-Ren Hou 侯敦仁 2005 學位論文 ; thesis 134 zh-TW
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language zh-TW
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description 碩士 === 國立中央大學 === 化學研究所 === 93 === The synthesis of 57 is based on the chiral oxazinone 59 as a chiral glycine enolate synthon. Asymmetric alkylation of 59 with 1,4-diiodobutane, deprotection and cyclization gave the 4-phenylhexahydropyrido[2,1-c][1,4] oxazin-1-one. Both enantiomers of pipecolic acid and 2-alkyl pipecolic acids were prepared by the epimerization or the second alkylation of 58 followed by hydrogenation.
author2 Duen-Ren Hou
author_facet Duen-Ren Hou
Shin-Yi Hung
洪欣怡
author Shin-Yi Hung
洪欣怡
spellingShingle Shin-Yi Hung
洪欣怡
Enaantioselective Synthesis of Pipecolic Acids
author_sort Shin-Yi Hung
title Enaantioselective Synthesis of Pipecolic Acids
title_short Enaantioselective Synthesis of Pipecolic Acids
title_full Enaantioselective Synthesis of Pipecolic Acids
title_fullStr Enaantioselective Synthesis of Pipecolic Acids
title_full_unstemmed Enaantioselective Synthesis of Pipecolic Acids
title_sort enaantioselective synthesis of pipecolic acids
publishDate 2005
url http://ndltd.ncl.edu.tw/handle/57848743957042874656
work_keys_str_mv AT shinyihung enaantioselectivesynthesisofpipecolicacids
AT hóngxīnyí enaantioselectivesynthesisofpipecolicacids
AT shinyihung héchéngjùyǒuguāngxuéhuóxìngzhīliùqīngyānjiǎnsuānpipecolicacid
AT hóngxīnyí héchéngjùyǒuguāngxuéhuóxìngzhīliùqīngyānjiǎnsuānpipecolicacid
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