Study on the Synthesis and Cytotoxic Activity of the Derivatives of Osthol

• Main Author: 廖立民
• Other Authors: 莊祚敏
• Format: Others
• Language: zh-TW
• Published: 2005
• Online Access: http://ndltd.ncl.edu.tw/handle/92910044933283872543

碩士 === 國立交通大學 === 應用化學系所 === 93 === Cnidii fructus, the dried mature fruits of Cnidium monnieri (L.) Cusson (Umbelliferae), is used as a tonic agent in traditional Chinese medicine. In modern medical study，osthol could induce apoptosis in HL-60 cells 2, 3. So we choose osthol and feurlic acid to develop a series of derivatives. We used the derivatives to do the MTT assay test and to discuss the SAR, the result teld us the isoprenyl group and the 3,4-olefinic bond of osthol is essential for its activity，and the isoprenyl group at position 8 had the better cytotoxicity. When osthol and demethylsuberosin reacted with ferulic acid to form the derivatives of (26) and (35) have the better effect of anti-cancer and IC50 value than osthol. So the derivatives of (26) and (35) can be the lead compounds to develop the anticancer drug. Therefore, because curcumin not only had the good effect to anticancer, but also to anti- inflammation. So we believe the derivatives has the good effect to anti-inflammation.