| Summary: | 碩士 === 國立成功大學 === 行為醫學研究所 === 93 === Although minor, negative finding on birth outcome of prenatal antidepressant exposure have been reported, the long-lasting effects are suspected in this regard. In this study, four antidepressants targeting varied neurotransmitter, bupropion (norepinephrine and dopamine reuptake inhibitor), trazodone (5-HT2 antagonists and serotonin reuptake inhibitor), citalopram and fluvoxamine (selective serotonin reuptake inhibitor) were used to assess the prenatal exposure effects of these antidepressants on cocaine reward, locomotion and naïve anxiety level in adult mice. Female C57BL/6J mice were treated with daily subcutaneous bupropion (25 or 12.5mg/kg), citalopram (5mg/kg), fluvoxamine (10mg/kg), trazodone (20mg/kg), or saline during their third trimester of gestation. On the postpartum day 56, mice were evaluated their locomotor activity and native anxiety using elevated plus maze. Then they underwent conditioned place preference (CPP) trainings to associate the euphoric effects of cocaine (5 mg/kg, i. p.) in a 3-day paring protocol. We found that trazodone pretreatment produced a higher mortality rate. Moreover, our result revealed that prenatal antidepressant exposure did not affect the locomotor activity and native anxiety. Mice prenatal exposure of citalopram, fluvoxamine, trazodone or saline all showed indistinct cocaine-associated CPP. However, mice prenatal exposed to bupropion at 25 mg/kg showed higher level of the cocaine-associated CPP as compared to the saline group, but those with 12.5 mg/kg did not reveal such elevation. Further studies are needed to investigate the effects of prenatal bupropion exposure on the brain neurotransmitters.
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