Synthesis of Pyrazole-Based DHODase Inhibitors via 1,3-Dipolar Cycloaddition of Sydnone

碩士 === 國立成功大學 === 化學系碩博士班 === 93 === 　Derivatives of pyrazole have biological activities and pharmacological actions had been reported by many researchers, such as : Anti-cancer, analgesics, antipyretic...etc. Many molecules containing pyrazole were also used in organic light-emitting diode in recen...

Full description

Bibliographic Details
Main Authors:	Tse-Hsin Chen, 陳哲欣
Other Authors:	Mou-Yung Yeh
Format:	Others
Language:	zh-TW
Published:	2005
Online Access:	http://ndltd.ncl.edu.tw/handle/28687123574868362689

id	ndltd-TW-093NCKU5065044
record_format	oai_dc
spelling	ndltd-TW-093NCKU50650442017-06-02T04:42:02Z http://ndltd.ncl.edu.tw/handle/28687123574868362689 Synthesis of Pyrazole-Based DHODase Inhibitors via 1,3-Dipolar Cycloaddition of Sydnone 以雪梨酮進行1,3-偶極環化加成反應合成具有pyrazole結構之DHODase抑制劑 Tse-Hsin Chen 陳哲欣碩士國立成功大學化學系碩博士班 93 　Derivatives of pyrazole have biological activities and pharmacological actions had been reported by many researchers, such as : Anti-cancer, analgesics, antipyretic...etc. Many molecules containing pyrazole were also used in organic light-emitting diode in recent years. 　Pyrazole analogues were demonstrated to be potent inhibitors of H. Pylori DHODase. These compounds are competitive with coenzyme Q6 and were highly selective for H. pylori over human DHODase. In our work, a new efficient synthesis method of pyrazole (5) was developed via 1,3-dipolar cycloaddition of sydnone with acetylene, Ritter reaction and amination.The chemoslectivity of sydnone derivatives with acetylene would be studied to improve the desired yield in 1,3-dipalor cycloaddition. Mou-Yung Yeh 葉茂榮 2005 學位論文 ; thesis 80 zh-TW
collection	NDLTD
language	zh-TW
format	Others
sources	NDLTD
description	碩士 === 國立成功大學 === 化學系碩博士班 === 93 === 　Derivatives of pyrazole have biological activities and pharmacological actions had been reported by many researchers, such as : Anti-cancer, analgesics, antipyretic...etc. Many molecules containing pyrazole were also used in organic light-emitting diode in recent years. 　Pyrazole analogues were demonstrated to be potent inhibitors of H. Pylori DHODase. These compounds are competitive with coenzyme Q6 and were highly selective for H. pylori over human DHODase. In our work, a new efficient synthesis method of pyrazole (5) was developed via 1,3-dipolar cycloaddition of sydnone with acetylene, Ritter reaction and amination.The chemoslectivity of sydnone derivatives with acetylene would be studied to improve the desired yield in 1,3-dipalor cycloaddition.
author2	Mou-Yung Yeh
author_facet	Mou-Yung Yeh Tse-Hsin Chen 陳哲欣
author	Tse-Hsin Chen 陳哲欣
spellingShingle	Tse-Hsin Chen 陳哲欣 Synthesis of Pyrazole-Based DHODase Inhibitors via 1,3-Dipolar Cycloaddition of Sydnone
author_sort	Tse-Hsin Chen
title	Synthesis of Pyrazole-Based DHODase Inhibitors via 1,3-Dipolar Cycloaddition of Sydnone
title_short	Synthesis of Pyrazole-Based DHODase Inhibitors via 1,3-Dipolar Cycloaddition of Sydnone
title_full	Synthesis of Pyrazole-Based DHODase Inhibitors via 1,3-Dipolar Cycloaddition of Sydnone
title_fullStr	Synthesis of Pyrazole-Based DHODase Inhibitors via 1,3-Dipolar Cycloaddition of Sydnone
title_full_unstemmed	Synthesis of Pyrazole-Based DHODase Inhibitors via 1,3-Dipolar Cycloaddition of Sydnone
title_sort	synthesis of pyrazole-based dhodase inhibitors via 1,3-dipolar cycloaddition of sydnone
publishDate	2005
url	http://ndltd.ncl.edu.tw/handle/28687123574868362689
work_keys_str_mv	AT tsehsinchen synthesisofpyrazolebaseddhodaseinhibitorsvia13dipolarcycloadditionofsydnone AT chénzhéxīn synthesisofpyrazolebaseddhodaseinhibitorsvia13dipolarcycloadditionofsydnone AT tsehsinchen yǐxuělítóngjìnxíng13ǒujíhuánhuàjiāchéngfǎnyīnghéchéngjùyǒupyrazolejiégòuzhīdhodaseyìzhìjì AT chénzhéxīn yǐxuělítóngjìnxíng13ǒujíhuánhuàjiāchéngfǎnyīnghéchéngjùyǒupyrazolejiégòuzhīdhodaseyìzhìjì
_version_	1718454679381213184

Synthesis of Pyrazole-Based DHODase Inhibitors via 1,3-Dipolar Cycloaddition of Sydnone

Similar Items