| Summary: | 碩士 === 高雄醫學大學 === 職業安全衛生研究所碩士班 === 93 === Objective：
Our study aim is to use urine cotinine level to verify the environmental tobacco exposure (ETS) evaluated by questionnaire among women in the Kaohsiung city.
Methods：
A community-based case-control study was conducted. The potential study subjects were from the data of Bureau National Health Insurance between January and December, 2000. Eligible cases and controls were female who were 40 years old and over and had lived in Kaohsiung city for 5 years and over. Potential study cases were those who were diagnosed with chronic bronchitis (ICD-9 code: 491) without other respiratory diseases at least 2 times in the year 2000. Potential controls were those who were healthy and were excluded other airway diseases. Questions about potential environmental risk factors, pulmonary function test, and one-spot urine sample were collected from each study woman. Continine level was measured by LC/MS/MS.
Result：
In total, 171 women（4 smokers and 167 non-smokers） provided their urine samples for cotinine measurements. Mean（±SE, range） cotinine levels in smokers （n=4）were 184.45 ng/mL（± 355.21 ng/mL, 1.36－717.22 ng/mL）, significantly higher than those in non-smokers（n=167, 6.85 ± 69.29 ng/mL, 0.08－896.60 ng/mL）（p=0.005）. We feather analyzed 67 women who had information about the smoking status in 3 days and 24 hours prior to urine collection. No study women had smoked cigarettes. The cotinine level among 23 women who had ETS exposure in these three days（2.72 ± 3.02 ng/mL, 0.13－12.45 ng/mL） were significantly higher than those without ETS exposure（n=44, 0.79 ± 0.63 ng/mL, 0.14－3.36 ng/mL）（p < 0.001）. The cotinine level among 9 women who had ETS exposure during the past 24 hours（3.08 ± 3.81 ng/mL, 0.53－12.45 ng/mL） were significantly higher than those without ETS exposure（n=58, 1.21 ± 1.51 ng/mL, 0.13－9.34 ng/mL）（p=0.017）. The high correlation was also noted between the amount （cigarette stick）of ETS exposure and urinary cotinine levels （Spearman correlation coefficiency, r=0.56, n=23, p=0.01）.
Discussion:
The study suggests that the smoking status among women can be correctly estimated by our questionnaire.
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