| Summary: | 碩士 === 高雄醫學大學 === 職業安全衛生研究所碩士班 === 93 === In general, occupation is still the major factor contributes to lead exposure. However, lead exposure is not limited to occupation factor only. Besides, the working environment which is associated with exposure to lead, people may exposed to low concentration of lead in their daily life without known. Lead is not necessary element for human, high exposure to lead which caused harm to health had already been testified. And the average concentration of lead in blood steadily declined in Taiwan in past one or two decades. However, low-dosage lead in blood is still harmful that should not be neglected, especially for female reproduction study.
A cross-sectional study was conducted. A total of 230 female students (age, mean: 15.86 years old, range15-17 years old) were recruited as subjects. Data of blood lead levels (BLLs), female hormones (estrogen, progesterone etc. Venous blood samples was taken during their early follicular phase on the third-fourth day of the menstrual cycle as the standard), and questionnaire were collected. To know the effects of blood lead level on female hormone 230 puberty in girls.
The results showed that it is significant correlation (P=0.01) between low blood lead levels (1.1-5.5μg/ dl) and estrogen(E2) during the early stage of follicle. After we adjust the other confounding factors by multiple linear regression analysis, it is still show that significant correlation (P<0.01) between blood lead levels with the estrogen of serum. On the other hand, no significant correlation (P=0.41) between low blood lead levels (1.1-5.5μg/ dl) with the progesterone(P4) of serum, even after adjusting the other factors. In conclusion, lead may affect estrogen (E2) during the early follicular phase among female adolescents, even under the low-dosage lead in blood that may increase the risk of infertility.
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