| Summary: | 碩士 === 高雄醫學大學 === 藥學研究所碩士在職專班 === 93 === Drug interactions are worth to emphasize in safety use of drugs. A number of drugs are introduced into the market every year, and patients who have been identified drug-drug interactions between the new approved drug and other medications would be reported in medical literature. Based on safety concern of patients, to discovery drug interactions beforehand is very important. So we attempted to find a way to uncover some possible and hidden drug-drug interactions of a new drug.
We used a text mining tool created by Swanson and Smalheiser called ARROWSMITH that facilitates the discovery of plausible hypotheses linking findings across specialties. By creating suggestive juxtapositions of searched and filtered records, ARROWSMITH is a useful tool for scientific discovery but not in itself a mechanism of scientific discovery. Digoxin and repaglinide were used as the model drugs to validate if ARROWSMITH could satisfy what we need in the area of identifying drug-drug interactions. Then we studied drug-drug interactions of some newly approved drugs, which included rosuvastatin, duloxetine, eplerenone, ezetimibe and memantine.
In summary, we have found some hidden but possibly potential drug-drug interactions with rosuvastatin or duloxetine and they must further evaluation to comfirm. Based on results of eplerenone, ezetimibe and memantine, we could not uncover some possible and hidden drug interactions for those drugs.
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