CREATING A JAVA GUI (JGuiB) FOR THE PHARMACOKINETIC/PHARMACODYNAMIC COMPUTER PROGRAM-BOOMER

• Main Authors: Ying-Hao Lu, 呂英豪
• Other Authors: Yung-Jin Lee
• Format: Others
• Language: en_US
• Published: 2005
• Online Access: http://ndltd.ncl.edu.tw/handle/87658492403779047927

碩士 === 高雄醫學大學 === 藥學研究所碩士班 === 93 === We have successfully created a GUI (graphical user interface) for Boomer, a simulation and modeling program for pharmacokinetic and pharmacodynamic (PK/PD) data analysis. We call this GUI as “JGuiB” which represents “Java GUI for Boomer”- the first GUI program for individual PK/PD software in the world. JGuiB includes the features of PK/PD modeling, data manipulation and function selections of Boomer, and can call Boomer to run with command-line mode. Normal fitting, simulation and Bayesian estimation are three main analysis methods of Boomer currently provided by JGuiB. Twenty frequently used PK/PD models with visualized modeling pictures are built and included with JGuiB. There are two of most particular features in JGuiB: 1) JGuiB with Boomer can easily apply to data analysis of multiple dosing and Bayesian estimation for clinical pharmacokinetic services, and 2) JGuiB enables Boomer to simultaneously work with more than one model for same data line using different weighting schemes in one project file. We selected Java (J2SE) as the program language to build JGuiB, and it has successfully turned the menu-driven mode of Boomer into a GUI-based application running in various platforms with Java virtual machine (JVM) and Boomer supported systems, such as Mac OS X, Windows and Linux systems.