| Summary: | 碩士 === 高雄醫學大學 === 藥學研究所碩士在職專班 === 93 === The study was to evaluate the prescribing patterns of antidepressants. Data were derived from the Psychiatric department in a medical center. The study included all new diagnosis outpatient users of antidepressants in the Psychiatric department in a medical center from October 1, 2003 to March 1, 2004.
There were 888 patients in the research of the study. Paroxetine was the most used antidepressant(45%). About half patient stop the first antidepressant at the beginning to treat major depression, 23% of patients take the antidepressant longer than 4 months, and 20.7% longer than 6 months. The average of response rate is 20.7%, but bupropion was lower(9.4%,P<0.05). The old group of paroxetine had higher response rate among male or female.
Paroxetine was the best studies selective serotonin reuptake inhibitor（SSRI） for generalized anxiety disorder（GAD） and the only SSRI to date approved by US Food and Drug Administration for this indication. In our study, the rate of utilization of paroxetine was higher in the group that patient had anxious disease at the same time. Otherwise it was different with fluoxetine. This was a noteworthy question.
The prescribing dosage of trazodone was lower than the other antidepressants, the adverse drug reaction incidence was lowest and the ratio of refractory to treatment was highest. The response rate of trazodone and the other antidepressants were not difference. Advise the doctor to increase the dosage of trazodone.
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